معرفی
Prof. Kodimangalam Ravichandran holds academic roles as a Professor at the University of Virginia (since 1996), Chair of the Department of Microbiology, Immunology & Cancer Biology (since 2010), and Director of the Center for Cell Clearance (since 2008). He is also a VIB Group Leader at the VIB-UGent Center for Inflammation Research (since 2017). His research focuses on cell clearance mechanisms in health and disease, particularly the engulfment of apoptotic cells and its anti-inflammatory consequences. He uses mouse and rat models to study signaling pathways, phagocytosis, and metabolite-driven tissue repair.
Education:
- PhD in Immunology, University of Massachusetts Amherst (1992)
- Postdoctoral Training at Harvard Medical School (1992–1996)
Research Interests:
- Apoptotic cell clearance and its role in inflammation/autoimmunity
- Find-me/eat-me signals (e.g., ATP/UTP, phosphatidylserine)
- BAI1 receptor signaling and cytoskeletal rearrangements
- Metabolic adaptations during phagocytosis
- Pyroptosis-driven tissue repair (recent breakthroughs)
Advising & Labs:
- PhD Students: Hannah De Cleene, Laura Boeckaerts
- Labs: Kodimangalam Ravichandran Lab (VIB-UGent), Center for Cell Clearance
Key Contributions:
- Identified nucleotides as 'find-me' signals (Nature 2009/2010/2014)
- Discovered BAI1 as a phosphatidylserine receptor (Nature 2007/2013)
- Highlighted anti-inflammatory outcomes of apoptotic clearance
- Recent work on pyroptosis-promoted wound healing (Nature 2024)
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