معرفی
Kinjal Majumder is an Assistant Professor in the Department of Oncology at the University of Wisconsin–Madison, with affiliations at the McArdle Laboratory for Cancer Research, the Institute for Molecular Virology, and the UW Carbone Cancer Center. His lab investigates how small DNA viruses manipulate host DNA damage response pathways and chromatin architecture to establish replication centers in the nucleus.
His research focuses on viral genome localization, chromatin dynamics, and host-pathogen interactions, particularly in Adeno-Associated Virus (AAV), Minute Virus of Mice (MVM), and Hepatitis B Virus (HBV). By using high-throughput chromosome conformation techniques like V3C, his lab maps viral interactions with host genomic sites, especially DNA damage regions and open chromatin, to understand mechanisms of viral persistence, oncogenesis, and therapeutic potential.
The recent publications highlight a consistent trend in studying how viral proteins (e.g., NS1, Rep) interact with DDR components (e.g., MRE11, ATR), induce replication stress, and exploit chromatin organization. These studies contribute to gene therapy vector development and oncolytic virus design. His lab actively engages in training and collaborates across disciplines in virology, epigenetics, and cancer biology.
Scientific Awards:
- No awards listed.
Advising and Grants: Dr. Majumder mentors a diverse team of graduate and undergraduate researchers across programs including Microbiology, Cell and Molecular Biology, Cancer Biology, and Pharmacology. His lab supports student training in molecular virology, bioinformatics, and experimental design. While specific grants are not mentioned, his research is likely supported by NIH or similar agencies given the scope and publication record.
Labs and Teams: The Majumder Lab is based at the R. M. Bock Laboratories and is part of the McArdle Laboratory for Cancer Research. The team includes graduate students, undergraduate researchers, and lab alumni, working collaboratively on projects related to viral replication, chromatin, and DNA damage. The lab emphasizes values such as scientific integrity, inclusion, and mentorship.
