Stephan Ludwig

Prof. Dr. Stephan Ludwig is a full professor and head of the Institute of Molecular Virology at the University of Münster, affiliated with the Zentrum für Molekularbiologie der Entzündung (ZMBE). His research focuses on understanding viral replication mechanisms, particularly influenza viruses, and developing antiviral therapies targeting host cell signaling pathways. He leads the Cells in Motion Cluster of Excellence, emphasizing advanced imaging techniques like STORM microscopy to visualize viral interactions within cells.

• Research Interests: Virology, molecular cell biology, virus-host cell signaling, innate immunity, oncogenic virus applications.
• Labs/Teams: Institute of Molecular Virology, Cells in Motion Cluster, collaborations on oncolytic virotherapy startups.

His work addresses how viruses hijack cellular pathways (e.g., MAPK, JNK, and NF-κB signaling) to replicate, with applications in MEK inhibitor therapies and SARS-CoV-2 research. Recent studies highlight synergies between oncolytic influenza viruses and immune checkpoint inhibitors for lung cancer.

Publications emphasize antiviral drug development, viral pathogenesis, and host immune responses. Notable contributions include identifying MEK inhibitors (e.g., Trametinib) as effective antivirals and elucidating influenza NS1 protein functions.

Grants and collaborations include funding for virology, inflammation imaging, and pandemic preparedness. Ludwig advocates translating basic research into clinical therapies, emphasizing societal responsibility in scientific innovation.