معرفی
Kevin Patrick Roarty, Ph.D., is an Assistant Professor in the Department of Molecular and Cellular Biology at Baylor College of Medicine. He is also a Member and Duncan Faculty Scholar at the Dan L Duncan Comprehensive Cancer Center. His research focuses on cancer biology, cell and developmental biology, particularly investigating the molecular mechanisms governing cellular heterogeneity in breast cancer progression and metastasis, with a focus on Wnt signaling pathways. He holds a PhD in Cell Biology from the University of Alabama at Birmingham, an MS in Forensic Science, and a BS in Biology/Biotechnology from Virginia Tech.
Roarty's work bridges cell, developmental, and cancer biology, studying how spatiotemporal cues regulate epithelial cell identity and multicellular movement during normal mammary gland development, and how these processes are co-opted during cancer metastasis. His research has explored roles of Ror2-mediated Wnt signaling in tumor cell invasion, branching morphogenesis, and cell-matrix adhesion. He has also contributed to developing tools like the pINDUCER lentiviral system for RNA interference.
Notable contributions include identifying non-canonical Wnt/Ror2 signaling's role in tumor invasion and metastasis, and investigating therapeutic resistance mechanisms in breast cancer using organoid models. His work has implications for understanding metastatic mechanisms and improving targeted therapies.
Awards and grants: No specific awards mentioned, but his research is funded through institutional and collaborative grants (details not provided in text).
Labs and teams: Leads the Roarty Laboratory at Baylor College of Medicine, collaborating with the Dan L Duncan Comprehensive Cancer Center.
