Kentaro Semba

Professor Kentaro Semba is a distinguished researcher at Waseda University's Faculty of Science and Engineering, School of Advanced Science and Engineering. With a Doctor of Science degree and impressive publication record of 140 papers, 7,934 citations, and an h-index of 43, he has established himself as a leading expert in cancer biology and molecular oncology.

His research focuses on critical areas in cancer biology:

• Molecular mechanisms of tumor biology and metastasis
• Cancer gene regulation and signal transduction pathways
• Development of transposon-based genetic screening systems
• Novel therapeutic approaches targeting metastasis mechanisms

Recent publications demonstrate his laboratory's expertise in breast cancer metastasis, particularly bone and lung metastasis in luminal and HER2-positive subtypes. His team has pioneered innovative reporter cell systems using transposon technology to study drug responses and cellular signaling pathways, leading to significant discoveries in c-Jun targeting for bone metastasis and c-Myc degradation for cancer therapy.

His notable recognition includes:

• Japanese Cancer Association Encouragement Award (1988)

Professor Semba maintains active professional memberships in the Japanese Society for Molecular Biology, Japanese Society for Cancer Metastasis, Japanese Society for Molecular Targeted Cancer Therapy, and the Japanese Cancer Association. His research group has developed sophisticated methodologies including transposon-mediated promoter trapping systems and in vivo screening systems for identifying tumorigenic genes and metastasis mechanisms.

His laboratory comprises specialized teams focused on:

• Cancer metastasis mechanisms research
• Transposon-based genetic screening technology
• Reporter cell system development
• Molecular characterization of breast cancer subtypes