Geyu Zhou

Dr. Geyu Zhou is an Assistant Professor in the Department of Biological Sciences at Purdue University, affiliated with the College of Science. Their research focuses on DNA G-quadruplex structures and their roles in gene regulation, particularly in oncogenes like MYC and PDGFR-β. Dr. Zhou's work spans structural biology, drug discovery, and cancer biology, emphasizing small molecule development to target G-quadruplexes for therapeutic purposes.

Research interests include understanding how G-quadruplex structures regulate key cancer-related genes, designing ligands to stabilize or destabilize these structures, and exploring their clinical applications. Dr. Zhou has pioneered methods such as custom G4 microarrays for large-scale ligand screening and employs advanced techniques like NMR spectroscopy and X-ray crystallography to elucidate structural mechanisms.

Recent studies highlight the therapeutic potential of indenoisoquinolines and berberine derivatives in MYC inhibition, as well as targeting FGFR1 in breast cancer through G-quadruplex stabilization. Their work bridges fundamental molecular biology with translational oncology, aiming to develop novel anticancer strategies.