Kelly Street

Kelly Street is an Assistant Professor in the Division of Biostatistics at the Keck School of Medicine of the University of Southern California (USC), where she conducts research at the intersection of biostatistics, computational biology, and genomics. Her work focuses on developing statistical and computational methods for analyzing high-dimensional biological data, particularly from single-cell sequencing technologies.

Her educational background includes a PhD in Biostatistics with a Designated Emphasis in Computational Biology (2018), an MA in Biostatistics (2014), both from the University of California, Berkeley, and a BS in Mathematics (2012) from the University of Chicago.

Kelly Street's research interests center on single-cell RNA sequencing (scRNA-seq), with a strong emphasis on trajectory inference to model continuous biological processes such as cell differentiation. She develops methods for differential expression and differential progression across conditions, enabling comparisons of developmental trajectories between experimental groups. Her work extends to multi-omics integration, combining data from diverse assays including ATAC-seq, WGBS, CyTOF, and TCR-seq to gain a more comprehensive understanding of cellular states and functions. She is an active contributor to the Bioconductor project, creating and maintaining software tools that support reproducible and scalable single-cell data analysis.

The analysis of her recent publications reveals a consistent focus on improving computational frameworks for single-cell genomics, particularly in modeling dynamic biological processes, enhancing data quality (e.g., CyTOF data cleaning), and enabling cross-condition comparisons in trajectory analysis. Her work bridges statistical theory with practical applications in immunology and cancer research.

• Invited speaker at major institutions including MD Anderson Cancer Center, Harvard T.H. Chan School of Public Health, and Northwestern University.
• Regular presenter at BioC and EuroBioc conferences, highlighting her active role in the Bioconductor community.
• Organizer and instructor for educational workshops such as the Healthcare Innovation Replicathon and Bioconductor training sessions.

Kelly Street has advised and collaborated on training programs for undergraduate and graduate students through REU programs and has contributed to open-source software development. While specific grant details are not mentioned, her active research program and workshop leadership suggest ongoing funding support. She has also collaborated with researchers at Dana-Farber Cancer Institute, as indicated by her email address and seminar presentations.

Her laboratory or research group appears to focus on developing statistical methods and software for single-cell analysis, likely involving a team of graduate students, postdocs, and collaborators working on trajectory inference, multi-omics integration, and immune profiling applications.