معرفی
Kai Tan, Ph.D. is a Professor of Pediatrics at the Children's Hospital of Philadelphia and the University of Pennsylvania. He serves as Director of the Center for Single-cell Biology and holds the Richard & Sheila Sanford Endowed Chair. Dr. Tan is affiliated with multiple institutions including the Abramson Cancer Center, Institute for Regenerative Medicine, and Epigenetics Institute at UPenn.
- Education
- B.S. in Biochemistry (1997), Beloit College
- Ph.D. in Computational Biology (2004), Washington University in St. Louis
- Research Interests
Dr. Tan's laboratory combines genomics, systems biology, and computational methods to study:
- Gene regulatory networks in cellular development
- Molecular mechanisms of therapeutic resistance in cancer
- 3D genome organization and cis-regulatory elements
- Multi-omics data integration using network biology
- Single-cell transcriptomics/proteomics/epigenomics
- Development of tools like CelloType and CytoTalk
- Recent Publication Trends
Dr. Tan's work focuses on:
- Single-cell multiomic atlases of pediatric cancers
- Network-based identification of disease pathways
- Computational methods for spatial omics analysis
- Understanding CAR T-cell persistence mechanisms
- Epigenetic regulation in hematopoietic development
- Signaling pathways in tumor microenvironment interactions
- Scientific Recognition
- Richard & Sheila Sanford Endowed Chair
- Director, Center for Single-cell Biology at CHOP
- Member, Multiple UPenn Institutes
- Advising
- Advised Dr. Jonathan Sussman (Ph.D. 2025)
- Laboratory
As Director of the Center for Single-cell Biology at CHOP, Dr. Tan leads an interdisciplinary team combining:
- Experimental scientists
- Computational biologists
- Clinician-scientists
- Multi-omics platform specialists
۰مقاله ثبتشده
.png)
