معرفی
Kaelyn Sumigray is an Assistant Professor in the Department of Genetics at Yale School of Medicine. She holds a PhD in Cell Biology from Duke University (2011) and postdoctoral training at UNC Chapel Hill and Duke University. Her research focuses on intestinal epithelial biology, stem cell dynamics, and morphogenesis, with particular interest in CFTR high-expresser cells and intestinal pathologies like cystic fibrosis and microvillus inclusion disease. She co-directs the Yale Summer Enrichment Research Experience (YSERE) and serves on multiple institutional committees including Yale Genetics Department Mentoring Committee and Yale Cancer Center.
Education
- B.S., Biology, Union College (2006)
- Ph.D., Cell Biology, Duke University (2011)
Research Interests
Dr. Sumigray investigates intestinal epithelial morphogenesis, stem cell niches, and disease mechanisms in cystic fibrosis and microvillus inclusion disease. Her lab uses organoid models and coculture systems to study epithelial-fibroblast interactions, CFTR function, and pH-sensing neuropod cells. Key themes include intestinal regeneration, cell polarity, and the role of serotonin in epithelial proliferation.
Publications Overview
Recent work highlights sex-specific effects of asparagine on colorectal tumors, lysosomal protein degradation mechanisms, and CFTR high-expresser cells' role in cystic fibrosis. Her articles span molecular biology, cell biology, and translational gastroenterology, emphasizing interdisciplinary approaches.
Awards
- Chen Innovation Award (2022)
- Dermatology Foundation Basic Research Award (2014)
Grants & Advising
Active in peer review for journals including Nature Cell Biology and the Journal of Clinical Investigation. Mentors students through Yale's Genetics Department and BBS program. Leads initiatives to enhance diversity in STEM through YSERE and institutional committees.
Labs & Teams
Leads the Sumigray Lab focused on intestinal epithelial biology. Collaborates with the Janeway Society and Yale Stem Cell Center on interdisciplinary projects.
