Jyoti Gupta

Jyoti Gupta is an Associate Research Scientist in Neuroscience at Yale School of Medicine. She holds a PhD in Biology from Wesleyan University (2018) and an MSc in Human Genetics from Guru Nanak Dev University (2010). Her research focuses on understanding and treating neurological disorders through stem-cell derived interneuron transplantation and synaptic dysfunction mechanisms. Key areas include GABAergic interneuron roles in epilepsy, neurodevelopmental disorders, and Parkinson’s disease. Gupta’s work combines experimental techniques like optogenetics and electrophysiology to study neural circuitry and therapeutic interventions.

Her research demonstrates how transplanted GABAergic interneurons can restore memory deficits and suppress seizures in mouse models, while recent studies explore the role of MEF2C transcription factors in parvalbumin interneuron survival. Collaborative projects highlight advancements in dopamine transporter dysfunction mechanisms linked to Parkinsonism. Gupta’s contributions bridge basic neuroscience with translational therapies targeting synaptic and circuit-level pathologies.

Advising and grants: No formal advisees listed, but her work involves interdisciplinary collaborations in regenerative medicine and neurodegenerative disease research. Active in lab teams focused on stem cell therapies and synaptic biology. No awards explicitly mentioned, though her publications reflect sustained contributions to epilepsy and Parkinson’s research.