معرفی
Dr. Justine Rudner is a Senior Lecturer at the Faculty of Medicine, University of Duisburg-Essen. Her research focuses on mitochondrial mechanisms in cancer therapy resistance, particularly the role of Bcl-2 family proteins in apoptosis regulation and radiotherapy efficacy.
- Investigates mitochondrial damage and reactive oxygen species (ROS) production in tumor cells
- Studies posttranslational regulation of anti-apoptotic proteins like Mcl-1
- Develops strategies to enhance radiotherapy through Bcl-2 inhibition
Her work explores how tumor hypoxia and mitochondrial protective mechanisms limit therapeutic outcomes, aiming to improve cancer treatments through targeted manipulation of apoptosis pathways.
Current research includes the use of compounds like ABT-199, ABT-263, and S63845 to inhibit Bcl-2 proteins, as well as the application of dihydroartemisinin to induce oxidative stress in mitochondria.
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