معرفی
Joseph D. Mancias, MD, PhD, is an Assistant Professor of Radiation Oncology at Harvard Medical School and an Investigator at the Hale Family Center for Pancreatic Cancer Research. He is affiliated with the Department of Radiation Oncology at Dana-Farber Cancer Institute and Brigham and Women’s Hospital in Boston, where he serves as Co-Director of the Pancreatic and Biliary Tumor Center. His dual clinical and research expertise positions him at the forefront of pancreatic cancer therapeutics and molecular biology.
Research Interests: Dr. Mancias’ research focuses on the molecular mechanisms of pancreatic ductal adenocarcinoma (PDAC), particularly the roles of selective autophagy and therapeutic resistance. His lab pioneered a quantitative autophagosomal proteomics workflow to identify key degradation pathways, leading to the discovery of NCOA4-mediated ferritinophagy as a critical dependency in PDAC. His work integrates biochemical, proteomic, gene editing, and mouse modeling techniques to uncover metabolic vulnerabilities and resistance mechanisms in cancer.
Publication Trends: His most recent publications (2022–2024) emphasize therapeutic resistance, tumor immune evasion, and KRAS-targeted therapies in pancreatic cancer. These studies employ cutting-edge proteomics and systems biology, revealing novel targets such as IRGQ-mediated autophagy and compensatory metabolic networks. His work bridges basic science and translational research, aiming to move findings into clinical trials.
- Scientific Awards:
No specific awards are mentioned in the provided text.
Advising and Grants: Dr. Mancias mentors a dynamic research team, including postdoctoral fellows and technicians. His lab is actively hiring and has hosted productive trainees such as Dr. Naiara Santana-Codina, who published multiple first-author papers. His research is supported by institutional funding and collaborative grants, particularly through the Hale Family Center for Pancreatic Cancer Research, enabling preclinical testing of novel therapies.
Labs and Teams: The Mancias Lab operates at the intersection of radiation oncology and cancer biology, collaborating closely with labs led by Dr. Alec Kimmelman and Dr. J. Wade Harper. The team employs a multidisciplinary approach, combining clinical insights with molecular discovery to advance pancreatic cancer treatment.
