Barbara M. Grüner

Prof. Dr. Barbara M. Grüner is a faculty member at the Department of Medical Oncology, University Hospital Essen, and affiliated with the West German Cancer Center (WTZ) and the Center for Molecular Medicine (ZMB). Her research centers on cell plasticity and metastasis in pancreatic and lung cancers, utilizing advanced patient-derived murine models and genetic tools.

Her research interests include:

• Molecular mechanisms of tumor metastasis
• Therapy resistance in pancreatic cancer
• Cell plasticity and tumor microenvironment
• In vivo modeling and CRISPR-based screening
• Metabolic and epigenetic drivers of metastasis

Her recent publications reveal a strong focus on pancreatic ductal adenocarcinoma (PDAC) and lung cancer, with work spanning genetic modeling, drug response, chromatin accessibility, and in vivo screening platforms. Her articles, published in top journals like Nature, Cell, and Nature Medicine, highlight her contributions to understanding metastatic cell states and therapeutic vulnerabilities.

She has not been mentioned with specific scientific awards or students in the provided texts.

She leads a research group focused on mechanistic oncology, collaborating with experts in proteomics, genetics, and pharmacology to advance personalized cancer therapy.