Josep Bartomeu Cladera Cerda

Josep Bartomeu Cladera Cerda is a Professor in the Department of Biochemistry and Molecular Biology at the Autonomous University of Barcelona, where he leads research at the Institute of Neuroscience (INc) and the Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics. With an active research career spanning from 1988 to present, he has produced 84 research outputs including articles, chapters, and reviews.

Dr. Cladera Cerda earned his Ph.D. from the Autonomous University of Barcelona on March 22, 1993, with a dissertation titled "Estudis de microcalorimetria i d'espectroscòpia d'infraroig sobre l'estructura de la bacteriorodopsina" (Studies of microcalorimetry and infrared spectroscopy on the structure of bacteriorhodopsin).

His research focuses on Alzheimer's disease mechanisms, particularly $$\text{A}\beta$$ peptide aggregation and interaction with biological membranes. He employs advanced techniques including synchrotron-based infrared imaging and dendrimer-based nanotherapeutics. His work bridges molecular biophysics, neuropharmacology, and bioinformatics to understand protein misfolding diseases.

Analysis of his recent publications reveals a strong focus on early-stage amyloid aggregate characterization in Alzheimer's disease models, with increasing emphasis on nanotherapeutic interventions using $$\text{G4-PPI-His-Mal}$$-dendrimers. His research spans from fundamental protein aggregation studies to translational applications.

• LIPID-BASED NANOSYSTEMS FOR BIOMEDICAL APPLICATIONS (2022-2026, European Regional Development Fund)
• Optimization of a nanotherapeutic delivery system based on dendrimers for Alzheimer's disease treatment (2018-2021, Spanish Ministry of Economy and Competitiveness)
• Structure-function studies of membrane proteins: transporters and receptors (2013-2015, Spanish Ministry of Economy and Competitiveness)

He leads the Laboratory of Molecular Neuropharmacology, Biophysics and Bioinformatics at the Institute of Neuroscience, where his team investigates the molecular mechanisms of neurodegenerative diseases with particular focus on protein aggregation phenomena and membrane interactions.