Joonbum Lee

Joonbum Lee is a Post-Doctoral Researcher in the Department of Animal Sciences at The Ohio State University. His primary research focuses on avian molecular genetics, particularly exploring the roles of genes like myostatin and melanophilin in muscle, adipose tissue, and feather development. He employs advanced techniques such as CRISPR-Cas9 genome editing and adenoviral delivery systems to study genetic modifications in poultry species.

Key research interests include: (1) Myostatin regulation of muscle and fat metabolism, (2) Melanophilin's role in melanocyte function and feather pigmentation, (3) Embryonic gene expression patterns influenced by retinoic acid and other factors, and (4) Eggshell structural properties linked to genetic mutations. His work bridges fundamental developmental biology with practical applications in poultry breeding and agricultural biotechnology.

Recent studies highlight breakthroughs such as creating myostatin-mutant quail with enhanced muscle hypertrophy and altered sexual dimorphism, as well as demonstrating regional feather color changes through localized CRISPR injections. These findings contribute to understanding genetic mechanisms in avian physiology with potential industrial applications in meat production and egg quality optimization.

His research also addresses challenges in genome editing efficiency, including validation of CRISPR guide RNAs and optimizing viral vector delivery methods for in vivo applications. While no specific awards are listed, his contributions reflect innovative approaches to avian genetic research.