Jonathan Kastan

Jonathan Kastan is a Researcher in Dr. David Tuveson’s laboratory at Cold Spring Harbor Laboratory, focusing on pancreatic cancer biology and mechanisms of intercellular communication under stress conditions. His research aims to develop novel diagnostic tools for early-stage pancreatic cancer detection. He completed his PhD at Duke University, studying innate immune evasion by poliovirus in Dr. Matthias Gromeier’s lab.

His research interests include pancreatic ductal adenocarcinoma (PDAC) pathogenesis, tumor microenvironment dynamics, secretome analysis, and the role of cellular stress pathways in cancer progression. He also investigates antiviral host responses and viral mechanisms of immune evasion.

Recent work highlights biomarker discovery (e.g., keratin-19 and gelsolin), RAS pathway therapeutic resistance, and the role of NF1-SPRED2 complexes in tumor promotion. His articles emphasize translational applications in cancer diagnostics and immunotherapy strategies leveraging viral signaling pathways.

Jonathan collaborates with lab members including Jeremy Nigri, Hudson Alakonya, and others, contributing to a multidisciplinary team advancing cancer biology research. No formal student advisees or grants are explicitly listed in the provided information.