معرفی
Brian Haab, Ph.D., is a Professor in the Department of Cell Biology at Van Andel Institute (VAI) and serves as an Assistant Dean of the Van Andel Institute Graduate School. He holds an adjunct role in Michigan State University's Department of Biochemistry and Molecular Biology. His research focuses on developing glycan-based biomarkers for early detection and treatment stratification of pancreatic ductal adenocarcinoma (PDAC), emphasizing tumor heterogeneity and metabolic signatures.
Education: Ph.D. in Chemistry, University of California, Berkeley (1998); Postdoctoral Fellowship at Stanford University under Patrick Brown.
Research Interests:
- Identification of glycan biomarkers distinguishing PDAC subpopulations
- Development of blood-based assays for early detection
- Linking glycan profiles to metabolic pathways and treatment responses
- Automated image analysis tools (SignalFinder, CarboGrove)
Key Projects:
- Multi-marker glycan assays for PDAC detection (e.g., CA19-9/STRA combinations)
- Metabolic classification of cancer cells via glycan synthesis patterns
- Clinical validation of biomarkers in blinded studies
Impact: Over 120 peer-reviewed papers, including high-impact journals. Co-founded clinical trials with VAI-SU2C and Cure Parkinson’s. Tools like SignalFinder and CarboGrove advance glycan research and diagnostics.
Grants/Awards: Not explicitly listed, but highlighted for contributions to pancreatic cancer research.
Labs/Teams: Haab Laboratory at VAI, collaborating with institutions like University of Pittsburgh and Michigan State University. Mentors doctoral students and postdoctoral researchers in glycobiology and translational oncology.
