Jonathan Bramson

Jonathan Bramson is a Professor and Vice Dean, Research at the Faculty of Health Sciences, McMaster University, holding the John Bienenstock Chair in Molecular Medicine. His work focuses on cell-based therapies for cancer, leveraging genetic engineering, synthetic biology, and chemical biology to enhance anti-tumor activity of white blood cells.

• Key Research Themes: Cancer immunotherapy, T cell engineering, oncolytic viruses, and tumor immunology.
• Pioneering Work: Development of TAC (T Cell Antigen Coupler) receptors for targeted cancer therapies, transitioning from lab to clinical trials in Canada and the USA.

Scientific Awards:

• John Bienenstock Chair in Molecular Medicine

Collaborative Impact: Co-founded a McMaster biotech start-up advancing immunotherapy for solid cancers. Led clinical trials like CYTOSHRINK for metastatic kidney cancer and explored metabolic modulators (e.g., canagliflozin) to improve radiotherapy outcomes.