John Paul Murad

John Paul Murad is an Assistant Professor of Research Medicine at the University of Southern California (USC). His research focuses on advancing immunotherapeutic strategies, particularly chimeric antigen receptor (CAR) T cell therapy, to combat solid tumors and metastatic cancers. His work emphasizes enhancing CAR T cell efficacy through engineering innovations, targeted delivery systems, and modulation of the tumor microenvironment.

Key research areas include:

• Regional delivery of CAR T cells to treat brain and peritoneal metastases
• Optimizing CAR T cell selectivity using extracellular spacers and antigen-dependent signaling
• Combining CAR T cells with oncolytic viruses and photothermal control for enhanced intratumoral activity
• Pre-clinical and clinical evaluation of CAR T therapies in prostate, breast, and ovarian cancers

Recent studies highlight advancements in overcoming immunosuppressive tumor environments, improving CAR T cell persistence, and targeting antigens such as PSCA, HER2, and TAG72. His translational work bridges molecular engineering with clinical applications, aiming to address challenges in solid tumor immunotherapy.

No scientific awards are listed in the provided profile. Collaborative grants or lab affiliations are not explicitly mentioned, though his publications suggest involvement in multi-institutional research networks.

Research teams and labs associated with his work are not detailed here, but his contributions span experimental biology, pre-clinical models, and early-phase clinical trials in oncology.