معرفی
Dr. Jonathan Bogan is a tenured Professor of Medicine (Endocrinology) and of Cell Biology at Yale School of Medicine. He serves as Associate Section Chief in the Section of Endocrinology and Metabolism, and is affiliated with the Department of Internal Medicine, the Department of Cell Biology, and the Yale Center for Molecular and Systems Metabolism. He directs the Cell Biology Core of the Yale Diabetes Research Center and is an active attending physician at Yale-New Haven Hospital.
- Professor of Medicine (Endocrinology), Yale School of Medicine
- Professor of Cell Biology, Yale School of Medicine
- Associate Section Chief, Endocrinology and Metabolism
- Director, Cell Biology Core, Yale Diabetes Research Center
- Co-Director, Energy and Metabolism Master Course (MD Curriculum)
- Assistant Director for Education, Yale MD-PhD Program
Dr. Bogan earned his B.S. in Electrical Engineering from Yale College and his M.D. from Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology. He completed his residency in Internal Medicine and fellowship in Endocrinology at Massachusetts General Hospital, where he also conducted research with Dr. Harvey Lodish at the Whitehead Institute.
His research centers on the molecular mechanisms of insulin action, particularly the regulation of GLUT4 glucose transporter trafficking in adipose and muscle cells. His lab discovered the TUG protein as a critical regulator of GLUT4 sequestration and insulin-stimulated translocation. Current work explores TUG proteolysis, ubiquitin-like modification, nuclear signaling, and the integration of metabolic and immune pathways. His studies utilize biochemical, cell biological, and genetically engineered mouse models to understand systemic metabolism.
Dr. Bogan’s recent publications reveal a deep integration of metabolism with immunology, vesicle dynamics, and gene regulation. His work on TUG cleavage has uncovered novel enzymatic pathways in insulin signaling, while studies on GLUT4-RIG-I interactions highlight metabolic control of antiviral immunity. The themes across his research include protein trafficking, post-translational modifications, and systems-level metabolic regulation.
Dr. Bogan has received numerous honors, including:
- NIH Physician-Scientist Award
- American Diabetes Association Career Development Award
- Smith Family Foundation Award for Excellence in Biomedical Research
- W.M. Keck Foundation Distinguished Young Scholar in Medical Research
- Elected Member, American Society for Clinical Investigation
- Elected Member, Interurban Clinical Club
- Fellow, American College of Physicians
He has served on multiple NIH and American Diabetes Association review panels and is actively involved in mentoring through the MD-PhD Program and research training. His lab fosters interdisciplinary collaboration, particularly with experts in imaging, immunology, and systems biology. He also contributes to medical education as co-director of the Energy and Metabolism course and through clinical teaching in endocrinology.
