Johnathan Tune

Johnathan Tune, PhD, is a Professor and Chairman of Physiology & Anatomy at the College of Biomedical and Translational Sciences, University of North Texas Health Science Center. His research focuses on mechanisms of coronary blood flow regulation in health and disease, particularly in obesity and diabetes. He leads projects funded by the National Heart, Lung, and Blood Institute and the American Heart Association, investigating myocardial oxygen delivery and ischemic injury. Key interests include metabolic syndrome's effects on coronary function and translational studies using large animal models. Over 119 publications span coronary vasodilation, ion channel physiology, and therapeutic interventions for cardiac dysfunction. Notable projects address heart failure with preserved ejection fraction and post-partum myocardial oxygen imbalances. His work integrates experimental and computational approaches to unravel complex cardiovascular mechanisms.

Education: BA in Biology from University of North Texas, PhD in Physiology from University of North Texas Health Science Center.

Research emphasizes integrative physiology, combining in vivo/ex vivo models to study coronary circulation. Active collaborations include multi-scale modeling of myocardial perfusion and investigating SGLT2 inhibitors' cardioprotective roles. Current grants explore post-partum coronary dysfunction and HFpEF mechanisms. Lab activities focus on ion channels, metabolic signaling, and vascular dysfunction in metabolic disorders.