Payman Zamani

Payman Zamani is an Assistant Professor of Medicine in the Cardiovascular Medicine division at the Perelman School of Medicine, University of Pennsylvania. His clinical expertise focuses on heart failure with reduced and preserved ejection fraction, with research emphasizing exercise intolerance, cardiometabolic interventions, and proteomic biomarkers.

• Education: BA from Dartmouth College (2001), MD from Harvard Medical School (2007), MTR (Master of Science in Translational Research) from University of Pennsylvania (2015)

Research interests span the following domains:

• Heart Failure: Mechanisms and therapeutic targeting of HFpEF and HFrEF
• Exercise Physiology: Skeletal muscle dysfunction, metabolic fuel utilization, and intolerance in heart failure
• Proteomics: Discovery of biomarkers for prognosis, subphenotyping, and treatment response
• Translational Therapeutics: Ketone esters, SGLT2 inhibitors, and nitrate-based interventions

Recent publications highlight his work on:

• Efficacy of ketone therapy in improving exercise capacity and metabolic profiles in HFpEF
• Proteomic associations of iron metabolism, SASP biomarkers, and arterial stiffness
• Randomized trials of potassium nitrate and spironolactone in heart failure
• Metabolic profiling of SGLT2 inhibitor interactions in cardiometabolic endpoints