معرفی
John Simms is a Lecturer in the School of Biosciences at Aston University, part of the College of Health and Life Sciences. His research focuses on molecular pharmacology and drug discovery, combining computational approaches with experimental techniques like organ-on-a-chip systems. Key areas include G protein-coupled receptor (GPCR) dynamics, ligand-receptor interactions, and membrane protein-lipid interactions. He leads the Biosciences Research Group (BRG) and collaborates on vascular modeling and biomedical engineering projects.
Research Interests:
- Computational modeling of drug-receptor interactions
- Development of physiologically relevant in vitro models (e.g., aortic arch systems)
- Role of oxidative stress in receptor signaling
- Allosteric modulation mechanisms in GPCRs
Recent Work Trends: Articles from 2021-2025 emphasize lipid oxidation effects on receptors, vascular flow modeling, and advanced drug screening methods. His work bridges computational predictions with experimental validation in biomedical contexts.
Lab & Teams: Active in the BRG, focusing on membrane protein studies and organ-on-a-chip technologies. Collaborates with engineering teams on vascular device testing and fluid dynamics systems.
