معرفی
John Ellis is a Professor in both the Department of Psychiatry and Behavioral Health and the Department of Neuroscience and Experimental Therapeutics at Penn State University. He is affiliated with the Penn State Neuroscience Institute and leads research in molecular neuropharmacology. His work focuses on muscarinic acetylcholine receptors, allosteric modulation, and G protein-coupled receptor (GPCR) signaling mechanisms.
Research interests include studying muscarinic receptor subtypes (M1-M5), allosteric ligand interactions, and receptor oligomerization effects on signaling. His lab explores these topics using pharmacological, biochemical, and cellular approaches, with applications to drug discovery and understanding neurological disorders.
Recent publications (2014-2024) emphasize structural-functional relationships in GPCRs, allosteric modulator effects on receptor activity, and translational research in zebrafish models. Projects have been funded by NIH institutes including the National Institute on Aging and National Institute of Neurological Disorders and Stroke.
Ellis has led 3 major grants studying muscarinic receptor subpopulations and platelet receptor models. Key topics include: Allosteric site regulation (100% focus in recent projects), muscarinic receptor subtype selectivity, and G-protein coupling mechanisms in monomeric vs oligomeric receptor configurations.
