معرفی
John Petrini is a Professor and the Paul A. Marks Chair of Molecular Cell Biology at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center. He chairs the Molecular Biology Program and is the Founder and Director of the MSK Functional Genomics Initiative. His research is integral to the Tri-Institutional PhD Programs in collaboration with Weill Cornell Medicine and Rockefeller University.
His research focuses on the molecular mechanisms of chromosome stability, DNA damage response, and repair pathways. His lab investigates the Mre11-Rad50-Nbs1 complex and its role in double-strand break repair and cell cycle checkpoint activation. Using yeast, mice, and organoid models, his team studies how defects in these systems lead to cancer predisposition and chromosome instability syndromes.
The recent publications highlight a growing interest in the intersection of innate immune signaling and DNA replication, as well as functional genomics of DNA repair genes. His work spans genetics, molecular biology, and cancer biology, with strong translational implications.
Scientific Awards and Distinctions:
- Paul A. Marks Chair in Molecular Cell Biology
- Chair, Molecular Biology Program, SKI
- Founder and Director, MSK Functional Genomics Initiative
- EIO Scholar Award (awarded to trainee Hexiao Wang)
- R35 Outstanding Investigator Award, NIGMS
Dr. Petrini leads a dynamic research team and mentors graduate students and postdoctoral fellows. His lab receives sustained funding, including a prestigious R35 grant, supporting long-term innovation in genome integrity research. He plays a key role in shaping functional genomics infrastructure at MSK.
His laboratory is actively involved in cutting-edge research using genetic, biochemical, and molecular approaches across model organisms. The team is particularly focused on linking basic DNA repair mechanisms to human disease, with implications for cancer therapy and diagnostics.
