معرفی
John Elsworth is an Adjunct Professor in Psychiatry at the Yale School of Medicine. With a PhD in Neuroscience from the University of London (1980), his research focuses on dopamine neuron biology in neurodegenerative and psychiatric disorders. He directs studies on dopamine neuron development, dysfunction, and age-related demise, using primate models to investigate oxidative stress, endocrine disruptors, and neuroprotective factors like paraoxonase-2 (PON2).
His work spans three core themes:
- Elucidating age-dependent vulnerability of dopamine neurons in Parkinson's disease and schizophrenia
- Developing pharmacological strategies targeting mitochondrial enzymes (e.g., PON2) for neuroprotection
- Advancing regenerative approaches via stem cell transplantation and gene therapy
Recent publications highlight his contributions to:
- PPARγ/PGC1α signaling in mitochondrial biogenesis
- Sex-specific neuroprotective mechanisms in primate brains
- Stem cell engineering for neural repair
Affiliated with the Stephen & Denise Adams Center for Parkinson’s Disease Research and the Yale Stem Cell Center, Elsworth collaborates with experts in neurology, pharmacology, and regenerative medicine. His research integrates molecular neuroscience with translational strategies, aiming to bridge developmental neurobiology and clinical interventions for age-related neurological conditions.
