Sowmithra

Sowmithra is a Postdoctoral Associate at Yale School of Medicine, affiliated with the Lim Lab. They hold a PhD in Biophysics from NIMHANS (2021), specializing in neurodegenerative diseases and stem cell biology. Their research focuses on understanding neurodegenerative mechanisms, developing stem cell-based models for Parkinson’s disease, and exploring therapeutic interventions using mesenchymal and pluripotent stem cells.

Key research areas include:

• Stem cell-derived models for neurodegenerative disorders
• Ethnic-specific genetic variations in Parkinson’s disease
• Neuroprotective mechanisms against hypoxic-ischemic injury

Publications highlight advancements in induced pluripotent stem cell generation for disease modeling, lysosome biogenesis in neurodegeneration, and functional recovery through stem cell transplantation. Their work bridges basic neuroscience with translational medicine, emphasizing regenerative strategies for neurological conditions.

Current projects involve analyzing TDP-43-related pathology and LRRK2 gene variants in Parkinson’s disease, leveraging both in vitro and animal models to validate therapeutic targets.