John Clemmer

John Clemmer, PhD, is an Assistant Professor in the Department of Physiology and Biophysics at the University of Mississippi Medical Center, School of Medicine. His research employs mathematical modeling to investigate integrative physiology, focusing on hypertension, chronic kidney disease, and heart failure with preserved ejection fraction. Dr. Clemmer develops and utilizes the HumMod model to simulate pharmacological and device-based therapies, creating virtual populations to predict clinical trial outcomes.

His research interests span:

• Cardiovascular and renal physiology
• Physiological modeling of salt sensitivity and antihypertensive therapies
• Racial disparities in hypertension and heart failure
• Renoprotective mechanisms of SGLT2 inhibitors
• Baroreflex activation therapy for obesity-induced hypertension

Dr. Clemmer has received numerous prestigious awards including the Arthur C. Guyton Award (2023) and multiple American Heart Association Fellowships. His publications demonstrate consistent focus on cardiorenal interactions, health disparities, and computational physiology approaches to disease modeling.

Laboratory activities include research training in integrative physiology with opportunities for postdoctoral fellows. Current grants support investigations into the impact of renal dysfunction in Black Americans with HFpEF and modeling of SGLT2 inhibition in hypertensive kidney disease.