معرفی
Associate Professor John Chen is affiliated with the Department of Microbiology and Immunology at the National University of Singapore (NUS), within the Yong Loo Lin School of Medicine. His research focuses on understanding the genetic mechanisms enabling Staphylococcus aureus to evolve and spread antibiotic resistance and virulence factors through bacteriophages and pathogenicity islands. He leads the Bacterial Pathogenicity Lab, investigating how lateral transduction and phage-mediated genetic transfer drive bacterial adaptation.
- Education: BA, PhD
- Key Research Themes: Horizontal gene transfer, antibiotic resistance, S. aureus pathogenesis, bacteriophage biology.
Recent work includes groundbreaking studies on genome hypermobility via lateral transduction (Science, 2018) and dual pathogenicity island transfer (Cell, 2023). His lab explores how phages and chromosomal islands facilitate bacterial evolution, with implications for public health and antibiotic development.
He has published extensively in high-impact journals such as Science, Cell, and ISME Journal. Research highlights include identifying novel mechanisms of gene transfer and characterizing phage-induced pathogenicity islands in Gram-positive bacteria.
Labs/Teams: Dr. Chen’s lab at NUS focuses on microbial pathogenesis and genetic adaptation, collaborating with international teams to advance understanding of bacterial evolution and virulence.
