معرفی
Univ.-Prof. Dr. med. Johannes Roth serves as Director of the Institute of Immunology at the Medical Faculty of the University of Münster. He is a member of the "Cells in Motion" Cluster of Excellence and actively participates in the CiM-IMPRS Graduate Programme as a supervisor and Research and Careers Committee member. His research focuses on understanding inflammatory processes at the molecular level, with particular emphasis on cells of the innate immune system and their role in both acute and chronic inflammation.
Professor Roth's research interests span pediatric rheumatology and immunology, innate immunity, phagocytes, endothelial cells, alarmins and DAMPs, and S100 proteins. In his interview, he emphasized that his work aims to identify molecular mechanisms that trigger and strengthen inflammatory reactions, with clinical applications in rheumatoid arthritis, infections, inflammatory intestinal diseases, allergies, and rare autoinflammatory diseases. His team has made significant contributions to understanding how alarmins like S100 proteins regulate inflammation processes, with the goal of developing diagnostic and therapeutic approaches that directly benefit patients.
Analysis of Professor Roth's recent publications (2018-2023) reveals a strong focus on inflammatory mechanisms, particularly the role of alarmins and S100 proteins in immune regulation across multiple disease contexts. His work spans immunology, molecular biology, rheumatology, and imaging technologies, with key research trends including investigating how inflammatory processes become chronic, understanding phagocyte behavior in different disease contexts, and developing diagnostic approaches based on inflammatory biomarkers. Notably, his team developed a biomarker that improved diagnosis of Systemic Juvenile Idiopathic Arthritis, enabling faster and more targeted therapy for critically ill children.
- Member of Research and Careers Committee
- Supervisor in CiM-IMPRS Graduate Programme
- Director of Institute of Immunology since active research period
- Former pediatrician with clinical experience informing research direction
Professor Roth leads the Roth Lab at the Institute of Immunology, which is deeply involved in the "Cells in Motion" research network. His team develops methods to genetically modify, multiply, and visualize immune cells in living organisms, reflecting his commitment to translating basic research into clinical applications. He has expressed particular interest in understanding the body's natural ability to regulate inflammation, believing this knowledge could lead to more efficient therapies with fewer side effects for inflammatory diseases.
