Joe Derisi

Joe Derisi, PhD, is a Professor at the University of California, San Francisco (UCSF). His research focuses on functional genomics, infectious diseases, and virology. His lab investigates malaria (Plasmodium falciparum), yeast molecular biology, and viral triggers of asthma. Key projects include developing genomic tools for pathogen detection (e.g., Remoscope for malaria diagnostics) and understanding host-pathogen interactions in diseases like COVID-19 and glioblastoma. Collaborations span global health initiatives, including studies in Cambodia and Uganda. His work bridges basic science and clinical applications, emphasizing metagenomics and autoantibody discovery. The Derisi Lab is internationally recognized for contributions to pathogen surveillance (e.g., IDseq platform) and translational research in immunology and oncology.

• Affiliations: UCSF School of Medicine, Department of Biochemistry & Biophysics (implied)
• Research Themes: Antimicrobial resistance, immunopathogenesis, and molecular diagnostics
• Technologies: Next-generation sequencing, phage display, metagenomics

Research Interests:

• Malaria: Drug target discovery, genome-wide approaches, and diagnostics
• Virology: Respiratory viruses, SARS-CoV-2 variants, and autoantibody profiling
• Immunology: Autoimmune mechanisms, cytokine signaling (e.g., IL-6 in glioblastoma)
• Global Health: Pathogen surveillance in resource-limited settings

Recent Article Trends: Focus on metagenomic sequencing for infectious disease diagnosis (e.g., stroke infections, asthma triggers), autoantibody mechanisms in autoimmune disorders, and translational applications of proteomics.

Grants & Collaborations: Extensive NIH funding, partnerships with global health organizations (e.g., CDC, WHO), and industry collaborations for diagnostic tool development.

Labs/Teams: Derisi Lab at UCSF, co-developer of IDseq platform for metagenomic analysis, and leadership in the California COVIDNet initiative.