معرفی
Jiyue Zhu is the Dorothy O. Kennedy Distinguished Professor at the Department of Pharmaceutical Sciences within Washington State University. His research focuses on telomere biology, cancer development, and aging mechanisms using genetically engineered mouse models.
- Postdoctoral training in cancer biology at University of California San Francisco
- PhD in biochemistry from Dartmouth College
- BS in biochemistry from Fudan University, China
His lab investigates the genetic and epigenetic regulation of the TERT gene, the development of HuT mice with human-like telomere homeostasis, and the application of these models to study melanoma prevention strategies. Research areas include:
- Replicative senescence mechanisms
- Humanized telomere biology in mice
- Role of telomere crisis in cancer evolution
- Immune-mediated tumor elimination strategies
HuT mice (Terth/h) exhibit telomere lengths and regulation patterns mirroring humans, enabling translational studies of aging, cancer, and drug toxicity. His work has secured funding from:
- National Institute on Aging (2022-2027)
- National Institute of General Medical Sciences (2023-2028)
- Department of Defense CDMRP (2023-2027)
The Zhu lab team includes researchers like Dr. Fan Zhang and Teann Manser, working on telomere-driven disease models and preclinical translational platforms.
