Jin He

Jin He is an Associate Professor in the Department of Biochemistry and Molecular Biology at Michigan State University. His research focuses on epigenetic mechanisms in gene regulation, particularly during development and in diseases like cancer and neurodevelopmental disorders. The He lab investigates dynamic epigenetic modifications at gene regulatory elements and their roles in lineage specification, cell fate determination, and tumorigenesis.

Key research areas include the functional roles of histone methyltransferases (e.g., ASH1L, SMYD5) and demethylases (e.g., KDM2B, KDM6B) in neural development, autism spectrum disorder (ASD)/intellectual disability (ID), and leukemia. His studies employ mouse models, drug interventions (e.g., vorinostat), and systems biology approaches to dissect epigenetic pathways.

Publications highlight interdisciplinary work in neuroscience, stem cell biology, and oncology, with a focus on translating epigenetic insights into therapeutic strategies. Collaborative projects include longitudinal omics studies and drug efficacy testing in disease models.