Jian-Dong Li

Professor Jian-Dong Li serves as Director of the Institute for Biomedical Sciences and the Center for Inflammation, Immunity & Infection at Georgia State University. His leadership spans multiple research initiatives focused on inflammatory diseases and host-pathogen interactions.

Dr. Li's educational background includes an M.D. from Tsingtao University School of Medicine (1983) and a Ph.D. in Biomedical Sciences from the University of California, San Francisco (1997).

His research program centers on molecular mechanisms of inflammation regulation, particularly inducible negative feedback systems involving deubiquitinases like CYLD. Key areas include:

• Tight regulation of inflammatory responses to prevent tissue damage
• Host survival mechanisms during Streptococcus pneumoniae and influenza infections
• Molecular pathways driving mucus overproduction in respiratory diseases
• Therapeutic development through drug repositioning strategies

His laboratory employs multidisciplinary approaches including molecular genetics, immunology, chemical biology, and transgenic animal models.

Analysis of his recent publications (2017-2022) reveals a strong focus on translational applications, with significant work on vinpocetine as an anti-inflammatory agent and exploration of CYLD's role across infectious and inflammatory conditions. The research consistently bridges fundamental signaling mechanisms with therapeutic development for respiratory diseases.

Dr. Li actively mentors doctoral candidates and leads collaborative research teams investigating novel therapeutic targets. His work integrates basic science with clinical applications through partnerships with pharmaceutical researchers.

His laboratory infrastructure supports comprehensive studies from molecular pathways to animal models of infection and inflammation, with particular expertise in:

• CYLD-mediated deubiquitination pathways
• TLR and NF-κB signaling networks
• Mucin regulation in otitis media and COPD
• Drug repositioning for inflammatory conditions