Jess Tait

Jess Tait is a Research Fellow at the Centre for Medicine Use and Safety, Monash University. Their research focuses on antimicrobial resistance mechanisms, mathematical modeling of drug efficacy, and pharmacodynamic analysis of antibiotics against bacterial pathogens like Pseudomonas aeruginosa. Tait collaborates extensively on multi-omics approaches to understand antibiotic resistance and develop novel antimicrobial strategies.

Research interests include:

• Quantitative systems pharmacology modeling of drug resistance
• Dynamic biofilm models for antibiotic evaluation
• Mechanisms of hypermutability and heteroresistance
• Antimicrobial combination therapy optimization
• Development of sustained-release antibiotic formulations

Recent work emphasizes:

• Elucidating resistance mechanisms to ceftolozane/tazobactam and meropenem
• Evaluating synergistic effects of inhaled antibiotics for cystic fibrosis patients
• Characterizing metabolic markers predictive of antibiotic resistance

Collaborations involve cross-disciplinary teams in microbiology, bioinformatics, and pharmaceutical sciences. Tait's work aligns with UN Sustainable Development Goals addressing health and well-being through innovative antimicrobial strategies.