معرفی
Dr. Luke Allsopp is an Associate Professor in Molecular Bacteriology at the National Heart & Lung Institute (NHLI), part of the Faculty of Medicine at Imperial College London. His research focuses on bacterial secretion systems, antimicrobial resistance, and biofilm formation in pathogens like Pseudomonas aeruginosa. He leads a team within the Respiratory Infections Section at the NHLI, located at the Royal Brompton Campus.
Dr. Allsopp holds affiliations with the Centre for Bacterial Resistance Biology, Institute of Infection, and Microbiome Network. He has secured funding from organizations including the BBSRC, Cystic Fibrosis Trust, and LifeArc. His lab explores how bacteria adapt to environmental challenges through secretion systems and biofilm programs, with a special emphasis on chronic respiratory pathogens in cystic fibrosis patients.
Research interests include:
- Gram-negative bacterial secretion systems (e.g., Type VI)
- Regulation of virulence factors and biofilm dynamics
- Mechanisms of antibiotic resistance and persistence
- Host-pathogen interactions in respiratory infections
Recent work highlights synergistic drug combinations (e.g., glatiramer acetate with tobramycin) and innovative models predicting CFTR gene therapy impacts on Pseudomonas biofilms. His team collaborates on the UK Cystic Fibrosis Infection Biorepository (UKCFIB) to accelerate antimicrobial development.
Advising and grants: Supervises competitive PhD candidates via Presidents Scholarship programs. Major funders include the Academy of Medical Sciences and ESCMID.
Lab/Team: Based in the Emmanuel Kaye Building, his group combines functional genomics, metabolomics, and structural biology to dissect bacterial pathogenesis mechanisms.
