Jesper Velgaard Olsen

Jesper Velgaard Olsen is a Professor and Deputy Center Director at the University of Copenhagen's Novo Nordisk Foundation Center for Protein Research (CPR) and leads the Olsen Group. His research focuses on quantitative, high-resolution mass spectrometry-based proteomics, particularly in characterizing signaling networks regulated by phosphorylation and other post-translational modifications. The group develops advanced offline peptide fractionation and enrichment methods combined with high-resolution Orbitrap tandem mass spectrometry to improve robustness and reproducibility in proteomic analysis.

The Olsen Group investigates functional selectivity in cell signaling, where different growth factors binding to the same receptor activate distinct pathways. They identified tyrosine phosphorylated residues as molecular switches determining cell fate and optimized workflows enabling deep human proteome analysis comparable to RNA-seq. Their work spans technology development and biological applications in diseases like acute myeloid leukemia.

Key group members include PhD Fellows, PhD Students, and Researchers such as Agnete Witness Præst Jensen, Charlotte Hjort, and Kristina Bennet Emdal. For collaboration or inquiries, contact Olsen via email jesper.olsen@cpr.ku.dk.