Jeremy Nathans

Jeremy Nathans is a Professor in the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. His research spans developmental neuroscience and the neurobiology of disease, with a focus on Frizzled receptors and their role in mammalian development.

His research interests include neural and vascular development, Wnt signaling, retinal biology, and the molecular basis of sensory systems. The Nathans laboratory employs gene manipulation in mice, cell culture models, and biochemical reconstitution to investigate molecular events in development and disease. Key areas include axon guidance, neural tube closure, retinal vascularization, and planar cell polarity.

The trends in his recent publications highlight a strong focus on neurovascular development, particularly through Wnt and Norrin signaling pathways. His work integrates single-cell genomics, structural biology, and mouse genetics to understand barrier formation, limb development, and disease models. Themes include Frizzled receptor function, endothelial cell biology, and transcriptional regulation in neural and vascular tissues.

Dr. Nathans has mentored numerous researchers and contributed to major advances in visual pigment genetics and retinal disease mechanisms. His laboratory has developed innovative technologies for genetic manipulation and visualization of cell populations in the mouse. He has secured significant research funding to support his work in developmental signaling and disease modeling.

He leads an active research lab focused on the molecular mechanisms of development, particularly in the visual system and central nervous system. The lab utilizes advanced techniques including genetically directed cell labeling, single-cell RNA sequencing, and structural analysis to dissect signaling pathways in vivo.