معرفی
Dr Jeremy Blaydes is an Associate Professor at the University of Southampton, specializing in cancer biology and stress-response pathways. His research focuses on transcriptional regulation mechanisms in cancer cells, particularly the roles of p53, HDM2/HDMX, and CtBP proteins in tumorigenesis and therapeutic responses. His work is conducted in the Somers Cancer Research Building, emphasizing interdisciplinary collaboration in cancer biology.
Research interests include understanding how stress-response pathways (e.g., hypoxia, oncogene activation) drive cancer progression and treatment resistance. Key projects involve HDM2 regulation of p53, CtBP’s role in breast cancer proliferation and chemotherapy response, and developing targeted therapies against these pathways. His group received the Breast Cancer Campaign Team of the Year 2011 for advancements in CtBP research.
Publications highlight regulatory mechanisms of HDM proteins, CtBP interactions with oncogenes, and translational applications in cancer therapy. Current work explores metabolic stress pathways and their therapeutic potential. Collaborations include pre-clinical drug development targeting HDM2 and CtBP for personalized cancer treatments.
