Jennifer E. Flythe

Dr. Jennifer E. Flythe is a Professor of Medicine at the University of North Carolina (UNC) Chapel Hill School of Medicine. She serves as Chief of the Division of Nephrology and Hypertension, Associate Director of the UNC Kidney Center, and Medical Director of UNC Dialysis Services. Her clinical work focuses on the management of acute and chronic kidney disease patients, with particular emphasis on hemodialysis patients at UNC Hospital and Kidney Center and its associated outpatient facilities.

Dr. Flythe completed her undergraduate studies at Duke University, attended medical school at the University of North Carolina at Chapel Hill, earned her MPH from Harvard School of Public Health, completed her residency at Oregon Health & Science University, and finished her nephrology fellowship through the Brigham and Women's Hospital/Massachusetts General Hospital Joint Program.

Her research program centers on identifying and understanding modifiable mortality determinants among maintenance dialysis patients and developing innovative treatment strategies to reduce these risks. She has a particular focus on hemodialysis procedural risk factors, with much of her work examining dialysis hemodynamics, fluid management, and blood pressure patterns among maintenance hemodialysis patients. Dr. Flythe is committed to incorporating patient-centered outcomes and preferences into her research to ensure patient priorities drive outcomes research. Her work spans comparative effectiveness research, patient-reported outcomes, and quality improvement initiatives in kidney disease care.

Analysis of Dr. Flythe's publication record reveals a strong focus on dialysis outcomes and kidney disease management. Her research spans clinical nephrology, patient-centered outcomes, and quality improvement in dialysis care. Recent publications address critical issues such as dialysis modalities, blood pressure management during dialysis, intradialytic complications, and the clinical relevance of uremic toxins. Her work frequently appears in high-impact journals including JAMA, Journal of the American Society of Nephrology, and Kidney International, demonstrating her significant contributions to the field of nephrology.

Dr. Flythe has been actively involved in national initiatives, contributing to Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conferences where she has helped shape guidelines on dialysis initiation, modality choice, access, and prescription, as well as blood pressure and volume management in dialysis.

Her clinical leadership extends to directing the UNC Dialysis Services, where she oversees the delivery of high-quality dialysis care to patients across multiple facilities. Dr. Flythe is deeply committed to stakeholder engagement in research design and implementation, ensuring that the perspectives of patients, clinicians, and other healthcare providers inform her work.