معرفی
Jeff Gelles is the Aron and Imre Tauber Professor of Biochemistry and Molecular Pharmacology at Brandeis University. His research focuses on single-molecule biochemistry and biophysics, particularly in gene expression, transcription regulation, and cytoskeletal network dynamics. He employs advanced single-molecule light microscopy and CoSMoS techniques to study molecular machines in reconstituted systems and cell extracts.
- Education
- B.A., Harvard University
- Ph.D., California Institute of Technology
- Key Research Areas
- Transcription and RNA processing
- Cytoskeletal organization
- Interdisciplinary approaches combining physical chemistry, Bayesian machine learning, and mathematical modeling
His lab develops methods to address the "crowd noise problem" in conventional biochemical studies by observing individual molecular complexes in real time. Recent publications highlight mechanisms of RNA polymerase recycling, σ70 retention during transcription, and DNA replication regulation. Lab members are affiliated with Brandeis' Biochemistry and Biophysics, Physics, and Quantitative Biology programs.
