Jean-Philippe Julien

Dr. Jean-Philippe Julien is a Professor in the Department of Biochemistry, leading a laboratory at The Hospital for Sick Children Research Institute. His research integrates biochemical, biophysical, immunological, and structural biology techniques to characterize surface glycoprotein receptors and antibody-antigen interactions.

• Focus areas: Structural immunology, vaccine development, antibody engineering, and infectious disease research.
• Applies integrative structural biology to design therapeutic molecules for malaria, HIV-1, cancer, and autoimmune diseases.

Dr. Julien's research trends emphasize

• Structure-based vaccine design against SARS-CoV-2, malaria, and HIV-1
• Multispecific antibody engineering for enhanced neutralization potency
• Structural analysis of immune complexes and pathogen interactions
• Translation of molecular insights into clinical applications

Scientific awards include

• Canadian Society for Molecular Biosciences New Investigator Award (2021)
• Amgen Young Investigator Award (2020)
• Canada Research Chair in Structural Immunology (2017)
• International Union of Crystallography Bragg Prize (2020)

His laboratory generates three-dimensional insights into antibody mechanisms, with applications in vaccine candidates and therapeutic antibodies. The team collaborates on targets related to malaria, HIV-1, cancer, and autoimmune diseases.