Javier Montenegro García

Professor Javier Montenegro García is an Oportunius Research Professor at the University of Santiago de Compostela's Department of Organic Chemistry and principal investigator at CiQUS. Award recipient includes an ERC Starting Grant (2015) and Human Frontier Science Program Grant (2017) for innovative work in dynamic cell-penetrating peptides and synthetic cytoskeletons.

Research focuses on:

• Topological control of supramolecular assemblies
• Dynamic covalent chemistry for membrane transport
• Peptide-based gene/drug delivery systems
• Self-assembled biomimetic nanomaterials

Key innovations:

• CRISPR-Cas9 delivery via hydrazone-modified peptides
• Boron cluster superchaotropic transporters
• Light-controlled biomembrane transport systems
• Self-regulated artificial cytoskeletons

Publications demonstrate advances in mitochondrial targeting agents, isomer-dependent surfactant assembly, and polymer coatings for biological interactions. Research intersects chemistry, biology, and nanotechnology to address therapeutic delivery challenges.