Jason Matthews

Jason Matthews is a Professor in the Department of Nutritional Sciences at the Faculty of Medicine, University of Oslo. He also holds a status-only professorship at the Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada. His research focuses on the aryl hydrocarbon receptor (AHR) and its target gene PARP7/TIPARP in the context of cancer, inflammation, and metabolic diseases.

• Current positions: University of Oslo (since 2015), University of Toronto (status-only since 2016)
• Education: PhD (2001, Michigan State University), BSc (1997, University of Western Ontario)

Matthews' research investigates how AHR and PARP7 enable cancer cells to evade immune detection and promote tumor growth. His work explores therapeutic strategies combining AHR/PARP7 inhibition with immunotherapy to combat cancer progression. Additional studies examine the AHR-PARP7 axis in chronic inflammatory conditions like obesity and atherosclerosis.

Recent publications highlight his team's work on AHR inhibition in pancreatic cancer, PARP7's role in interferon signaling, environmental pollutant impacts on immune gene expression, and novel chemical compounds targeting the AHR pathway. These studies employ cell biology, gene editing, genomics, and preclinical cancer models.

Collaborations span institutions including University of Toronto, Karolinska Institute, and University of Leeds, focusing on cancer immunology, nutritional sciences, and drug development.