Jane A. McKeating

Jane A. McKeating is a Professor of Molecular Virology at the University of Oxford's Nuffield Department of Medicine. She holds the Hans Fischer Senior Fellowship at the Technical University of Munich's Institute for Advanced Study (TUM-IAS) since 2015. Her research focuses on viral infections, particularly hepatitis B (HBV) and C (HCV), exploring how hypoxia and circadian rhythms regulate viral replication and pathogenesis. She has held roles at institutions including the University of Birmingham (2005–2017) and Rockefeller University (2000–2005).

Education:

• BSc in Biological Sciences, University of Warwick (1982)
• PhD in Virology, Royal Free Hospital School of Medicine, University College London (1987)

Research Interests:

Her work investigates how low oxygen (hypoxia) and circadian signaling pathways influence viral replication and tropism, particularly in liver and immune cells. Recent studies include SARS-CoV-2 regulation by hypoxia-inducible factors (HIFs) and circadian clock components like BMAL1. She also examines therapies targeting these pathways to combat viral infections.

Publications:

Her recent work spans hepatitis virus biology, antiviral screening tools, and circadian regulation of viral infections. Key themes include viral entry mechanisms, immune evasion, and drug development.

Awards:

• 2015 Founders Award, University of Birmingham
• 2006 Royal Society Wolfson Merit Award
• 1995 Fleming Award, Society of General Microbiology

Lab & Collaborations:

Her research group at Oxford focuses on viral-host interactions, with collaborations on spatial transcriptomics of HBV/HDV/HIV co-infections and antiviral drug screening platforms.