Severin O. Gudima

Severin O. Gudima is a Professor in the Department of Microbiology, Molecular Genetics and Immunology at the University of Kansas Medical Center School of Medicine. His research focuses on hepatitis B virus (HBV) and hepatitis delta virus (HDV), examining their infection mechanisms, host interactions, and contributions to hepatocellular carcinoma (HCC). He leads a laboratory dedicated to understanding chronic viral infections and developing antiviral strategies.

• University: University of Kansas Medical Center
• School: School of Medicine
• Department: Microbiology, Molecular Genetics and Immunology

Research Interests:
Gudima's work spans virology, molecular biology, and immunology, with a primary focus on HBV/HDV pathogenesis. His studies include viral RNA dynamics, envelope protein function, and the role of integrated viral DNA in chronic infection. He has pioneered the use of woodchuck models to investigate viral spread and immune responses.

Recent Article Trends:
His publications highlight HDV-HBV interactions, RNA modifications (e.g., N6-methyladenine), and innate immune responses in chronic hepatitis. Key subfields include viral replication, host-virus coevolution, and liver tumor infection models.