Susan L. Uprichard

Susan L. Uprichard is a Professor at the Stritch School of Medicine, Loyola University Chicago, and holds leadership roles as Director of Hepatology Research, Infectious Disease and Immunology Graduate Program, and Clinical Research Office Biobank. Her research focuses on hepatitis virus infections, particularly HCV and HBV, emphasizing experimental model development and antiviral strategies. She earned her Ph.D. in Virology from Harvard University. Her work includes identifying viral entry factors (e.g., NPC1L1 for HCV), optimizing treatments via mathematical modeling, and advancing HBV infection systems using NTCP receptors. She investigates liver pathology mechanisms and small animal models to study HCV-associated diseases like hepatocellular carcinoma.

Education

• Ph.D. in Virology, Harvard University

Research Interests

Dr. Uprichard's lab develops experimental systems to study viral-host interactions, including HCV entry mechanisms, cell-to-cell spread, and treatment response optimization. Her work integrates mathematical modeling to improve antiviral therapies and accessibility. For HBV, she focuses on NTCP-mediated infection models to study cccDNA-driven replication. She also explores HCV's species tropism and liver disease mechanisms in mice.

Awards & Grants

While specific awards are not listed, her leadership roles and prolific publication record reflect significant recognition in virology and hepatology. Her research is likely supported by grants in infectious disease and translational medicine.

Labs & Teams

Her lab collaborates on projects involving humanized mouse models, antiviral drug screening, and clinical trial design. Key collaborations include work on lonafarnib in hepatitis delta and silibinin in HCV.