معرفی
Jan Krumsiek is an Assistant Professor at Weill Cornell Medicine's Graduate School of Medical Sciences, affiliated with both the Physiology, Biophysics & Systems Biology and Computational Biology programs. His research sits at the intersection of metabolism, computational biology, and disease mechanisms.
Dr. Krumsiek's research focuses on how metabolism shapes health and disease across multiple conditions including neurodegeneration, cancer, and cardiometabolic disorders. His lab integrates metabolomics, proteomics, transcriptomics, and genomics with computational analysis to reveal actionable biomarkers and elucidate molecular mechanisms. Key ongoing projects investigate tau-related metabolic disruptions in Alzheimer's disease, the impact of dietary interventions on brain health, tumor escape pathways in resistant lymphomas via spatial metabolomics, and microbial biosynthetic clusters as therapeutic opportunities. The lab also utilizes large-scale NMR-based approaches to refine cardiometabolic risk models and investigate metabolic signatures tied to clinical outcomes in conditions like COVID-19.
Analysis of Dr. Krumsiek's recent publications (2023-2025) reveals a strong focus on Alzheimer's disease metabolism, with numerous studies examining how dietary interventions, particularly modified Mediterranean ketogenic diets, affect metabolic signatures in neurodegenerative conditions. His work also spans cancer metabolism, space medicine omics, and multi-omics integration methodologies. A notable trend is the application of computational frameworks to analyze complex metabolic data across different disease states and interventions.
Dr. Krumsiek leads the Krumsiek Lab, which employs a multidisciplinary approach combining wet-lab metabolomics techniques with advanced computational analysis. The lab's work spans from basic metabolic pathway analysis to clinical applications, with particular emphasis on translating metabolic findings into potential therapeutic interventions.
