معرفی
Jan B. Hoek is a Professor and Vice Chair for Research in the Department of Pathology, Anatomy & Cell Biology at the College of Life Sciences, focusing on systems biology of intracellular signaling networks in liver pathophysiology.
Education:
- PhD, University of Amsterdam (1972)
His research investigates ethanol-induced deregulation of cytokine/growth factor signaling, mitochondrial metabolism in apoptosis, and early signaling during liver regeneration. Key projects analyze growth factor networks using computational modeling, energy metabolism in regeneration, ethanol's disruption of calcium homeostasis, and apoptotic susceptibility mechanisms.
Recent publications demonstrate interdisciplinary approaches including genome-scale metabolic modeling, transcriptomics, and network analysis to study alcoholic liver disease, liver regeneration, and transplantation viability, with emphasis on sex differences and therapeutic targeting.
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Dr. Hoek leads a research laboratory integrating computational modeling with experimental studies to investigate liver signaling pathways and their dysregulation in disease states.
