معرفی
James Dowling is a Professor in the Department of Molecular Genetics at SickKids (The Hospital for Sick Children) in Toronto, Ontario, where he leads research focused on childhood muscle diseases and rare genetic disorders. His work bridges fundamental molecular mechanisms with therapeutic development within a major pediatric research hospital setting.
His core research interests include:
- Childhood muscle diseases
- Rare diseases
- Disease modeling
- Drug discovery (design, development, and screening)
- Gene discovery
- Zebrafish model systems
- Endolysosomal function in muscle biology
Dr. Dowling's laboratory employs zebrafish as a primary model organism to investigate pathogenic mechanisms and identify potential treatments, with particular emphasis on how endolysosomal pathways contribute to muscle pathology. This approach enables high-throughput screening of therapeutic candidates while maintaining physiological relevance to human disease processes.
Contact information:
- Email: james.dowling@sickkids.ca
- Phone: 416-813-8980
- Location: SickKids - Peter Gilgan Centre for Research and Learning, 686 Bay Street, 15-9703, Toronto, Ontario M5G 0A4
